Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
Elenco: Madonna , Rosanna Arquette , Aidan Quinn , Mark Blum , Robert Joy , Laurie Metcalf , Anna Levine , Will Patton , Steven Wright , John Turturro , Giancarlo Esposito , Richard Hell , Rockets Redglare , Annie Golden , Richard Edson , Ann Magnuson , John Lurie , Peter Maloney , Anne Carlisle , Victor Argo , José Angel Santana , Steve Bosh , Daisy Bradford , Mary Joy , Rosemary Hochschild , Iris Chacón , Shirley Stoler , J.B. Waters , Arto Lindsay , Henry Adler , Marty Gold , Michael R. Chin , Patrick John Hurley , Timothy Carhart , Curt Dempster , Shirley Kaplan , Lázaro Pérez , John Hoyt , Gary Ray , Gary Binkow , Michael Bramon , Joyce Griffen , Paul Austin , Richard S. Lowy , Donna Ritchie , Kim Chan , Michael Badalucco , Elie J. Boubli , Adele Bertei , Peter Castellotti , Wende Dasteel , Steve Eidel , Michael Kaufman , Ilene Kristen , Carol Leifer , Richard Portnow , Isabel García Lorca , Tim Ransom , Gilda Torterello , Stanley Burns , Sandy Dell , Robert Dahdah , Eddy Galland , Kevin Harris , David Kellman , Harsh Nayyar , Robert Shafran , Frank Stellato .