Jimmy is young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom... who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy -- bubble suit and all -- treks cross-country to stop her. Swoosie Kurtz, as Jimmy's overprotective mom, co-stars along with Fabio, who portrays the leader of a religious cult.
Elenco: Jake Gyllenhaal , Swoosie Kurtz , Marley Shelton , Danny Trejo , John Carroll Lynch , Dave Sheridan , Brian George , Patrick Cranshaw , Verne Troyer , Stephen Spinella , Ever Carradine , Geoffrey Arend , Beetlejuice , Pablo Schreiber , Matthew McGrory , Bonnie Morgan , Stacy Keibler , Zach Galifianakis , Steven Anthony Lawrence .