Opting to forego a picturesque fall wedding and elope in Las Vegas, Karen hops a plane to ""Sin City"" with fiance Lyle and faithful friends Will and Jack. After arriving, they bump into superstar Jennifer Lopez who is vacationing and agrees on behalf of Rosario to sing at the ceremony. Meanwhile, Leo returns from Cambodia to meet up with Grace at the wedding, but their reunion is delayed by a freak design accident.
Elenco: Eric McCormack , Debra Messing , Sean Hayes , Megan Mullally , Shelley Morrison .