Spider-Man and Agent Venom have been cracking down at defeating possible Sinister Six recruits like Shocker, Grizzly, and Beetle. When Doctor Octopus has made an entirely new symbiote even when Arnim Zola pairs him up with Dr. Michael Morbius, it takes control of Harry Osborn and now forces him to destroy Spider-Man and Agent Venom as the new Anti-Venom. Now Spider-Man and Agent Venom must work with Iron Patriot to free Harry from the Anti-Venom symbiote.