Odie runs away from home, sick of Garfield's cruelty towards him, but the new house he runs off to is the residence of a boy with the personality of a mad scientist named Nathan, who plans to use his new invention to transform Odie into a cockroach. Now it is up to Garfield to save Odie.
Elenco: Jason Marsden , Frank Welker , Gregg Berger , Wally Wingert , Julie Payne , Audrey Wasilewski , Laura Summer .