Dean is frantic after Sam collapses and the doctor tells Dean his brother won't make it. Desperate, Dean sends out an all points bulletin via prayer to every angel in the area, asking them to help his brother. In exchange, Dean will owe that angel a favor. Numerous angry angels race to find and kill Dean, but one, Ezekiel, gets to him first. Meanwhile, Sam fights for his life and must face some familiar demons to do so. Castiel struggles to survive without powers.
Elenco: Jensen Ackles , Jared Padalecki , Misha Collins , Alexander Calvert , Mark Pellegrino , Mark Sheppard , Alona Tal , Candice Accola , Felicia Day , Genevieve Padalecki , Jeffrey Dean Morgan , Julie McNiven , Katie Cassidy , Lauren Cohan , Osric Chau , Richard Speight Jr. , Rob Benedict , Samantha Ferris , Ty Olsson .