Amara unleashes a dark fog on a small town, causing everyone to go mad. Dean and Sam realize this is a stronger version of the original black vein virus Amara previously unleashed. They team up with the sheriff to protect the town but their old remedy no longer works. Meanwhile, Chuck returns with an interesting proposal.
Elenco: Jensen Ackles , Jared Padalecki , Misha Collins , Alexander Calvert , Mark Pellegrino , Mark Sheppard , Alona Tal , Candice Accola , Felicia Day , Genevieve Padalecki , Jeffrey Dean Morgan , Julie McNiven , Katie Cassidy , Lauren Cohan , Osric Chau , Richard Speight Jr. , Rob Benedict , Samantha Ferris , Ty Olsson .