The Sanada Ninjas have joined the Black Knights in the search for the Divine Medicine but the Sanada Ninjas will take over Japan. Meanwhile Yutaro has Professor Hans note book and reads it, he soon finds out that there is a medicine that can possibly cure any illness. The Black Knights are elites in their field and can be dangerous, they are after the Divine Medicine so they can sell it and gain money and start to rule the world. Kenshin figures out that the Divine Medicine is somewhere in Suwa Sea so they take a trip there, trying to find any hints Kenshin asks local people questions. As they are moving, Sanada Ninjas attack Kenshin and the others, the Oniwabanshu helped and stopped the attack. The ninjas retreated and went back to base, the head leader of that group was getting annoyed of the outsiders and was arguing with the leader of the ninjas, the Black Knights step in and fight that particular group. Later on, Misao tags along with Kenshin and they get ready to get into Sanada's base.