Spider-Man, Iron Man, Thor and Hulk stand powerless after being struck by Dr. Doofenshmirtz's power-draining "inator." Once the supervillains – Red Skull, Whiplash, Venom and M.O.D.O.K. – find out that Dr. Doofenshmirtz is responsible for robbing the superheroes of their powers, they seek him out and together create mayhem in Danville. Meanwhile, Phineas and Ferb do everything they can to restore the superheroes' powers before the evil villains take over the world.
Elenco: Vincent Martella , Thomas Brodie-Sangster , Ashley Tisdale , Dan Povenmire , Dee Bradley Baker , Alyson Stoner , Bobby Gaylor , Maulik Pancholy , Caroline Rhea , Richard O'Brien , Kelly Hu , Mitchel Musso , Jeff 'Swampy' Marsh , Tyler Alexander Mann , Kari Wahlgren , Olivia Olson , Ariel Winter , John O'Hurley , Jane Carr , Malcolm McDowell , Barry Bostwick , Allison Janney , Madison Pettis .