The residents determine their future as they make their final decisions regarding post residency positions; Mark admits to Derek that he is torn between his love for Lexie and the fact that Julia can give him everything he's ever wanted; Ben plans something extra special for Bailey, but she is preoccupied with her work; and Arizona encourages her childhood friend, Nick, to have surgery. Meanwhile a couple on their third honeymoon come to the hospital complaining of mysterious symptoms.
Elenco: Ellen Pompeo , James Pickens Jr. , Chandra Wilson , Justin Chambers , Kevin McKidd , Jesse Williams , Patrick Dempsey , Sara Ramirez , Sandra Oh , Jessica Capshaw , Sarah Drew , Camilla Luddington , Caterina Scorsone , Giacomo Gianniotti , Kelly McCreary , Katherine Heigl , Chyler Leigh , Eric Dane , Kim Raver , T.R. Knight , Jerrika Hinton , Jason George , Isaiah Washington , Kate Walsh , Martin Henderson , Brooke Smith , Jake Borelli , Greg Germann , Chris Carmack , Tessa Ferrer , Gaius Charles , Anthony Hill , Richard Flood .