Chuck hosts a "Saints and Sinners" masquerade party at the Empire Hotel. At the party, Dan and Nate don't know what to make of Serena's strange behavior and mixed messages. Blair sets her sights on becoming the new face of Anne Archibald's foundation for girls, but Anne is concerned that Blair's friendship with Chuck Bass may be problematic.
Elenco: Blake Lively , Leighton Meester , Penn Badgley , Chace Crawford , Ed Westwick , Kelly Rutherford , Matthew Settle , Kaylee DeFer , Jessica Szohr , Kaylee De Fer , Kelly Rutherford , Kristen Bell , Matthew Settle , Michelle Trachtenberg , Taylor Momsen .