"It girl" Serena van der Woodsen has returned to Manhattan after a mysterious and self-imposed exile to boarding school. Serena's best friend, Blair Waldorf, has conflicted feelings about her friend's return since she has enjoyed being the Queen Bee during Serena's absence and might not be ready to relinquish her new position on the social ladder, not to mention the fact that she has always suspected there may be unspoken feelings between Serena and her longtime boyfriend, Nate.
Elenco: Blake Lively , Leighton Meester , Penn Badgley , Chace Crawford , Ed Westwick , Kelly Rutherford , Matthew Settle , Kaylee DeFer , Jessica Szohr , Kaylee De Fer , Kelly Rutherford , Kristen Bell , Matthew Settle , Michelle Trachtenberg , Taylor Momsen .