A frantic Sam and too-calm Luka report diabetic Alex missing after he runs away to find his father. Acting on information from the police, they follow a lead to Iowa, then eventually head for Colorado. As they travel, they discuss their relationship, slowly realising they have very little in common. With Alex safe, Sam tells him the truth and takes him to see his father. In the ER, Susan, Pratt, and the nurses evaluate Ray, Neela, and Abby’s first days as R2s, while each of them struggle to manage patients, new interns, and their first attempts at teaching - badly.
Elenco: Maura Tierney , Parminder Nagra , Scott Grimes , Linda Cardellini , John Stamos , David Lyons , Angela Bassett , Laura Innes , Lily Mariye , Linda Cardellini , Maura Tierney , Mekhi Phifer , Noah Wyle , Parminder Nagra , Scott Grimes , Sherry Stringfield , Yvette Freeman , Eriq La Salle , Kellie Martin , John Stamos , Michael Michele , Erik Palladino , Angela Bassett , David Lyons , Chase Masterson , Swoosie Kurtz , Lisa Vidal , Laura Cerón .