In the aftermath of tragedy with Bree's son Andrew running over Carlos' mother Juanita Solis, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike's real reason for moving to the street. Lynette reaches the breaking point in her addiction to the twins' ADD medication as she tries other measures like acupuncture to release her stress. The mysterious Mr. Shaw gets down to business as he develops a relationship with Edie. Lastly, Gabrielle confesses her adulterous affair to a priest while Carlos' mother Juanita is in the hospital.
Elenco: Felicity Huffman , Eva Longoria , Teri Hatcher , Marcia Cross , Brenda Strong , James Denton , Doug Savant , Charles Mesure , Madison De La Garza , Vanessa Williams , Jonathan Cake , Andrea Bowen , Beau Mirchoff , Brenda Strong , Charles Mesure , Charlie Carver , Cody Kasch , Doug Savant , Dougray Scott , Drea de Matteo , Helena Mattsson , James Denton , Jeffrey Nordling , Jesse Metcalfe , Josh Henderson , Joshua Logan Moore , Joy Lauren , Kathryn Joosten , Kendall Applegate , Kyle MacLachlan , Lyndsy Fonseca , Madison de la Garza , Maiara Walsh , Mark Moses , Mason Vale Cotton , Max Carver , Nathan Fillion , Neal McDonough , Shawn Pyfrom , Steven Culp , Vanessa Williams .