After being bitten by tiny green ghost beetles, the kids of Casper High get a mysterious illness that gives them ghost powers and are quarantined at a spooky old hospital outside of town. When Danny sneaks into the hospital to investigate, he is captured by Penelope Spectra and her assistant, Bertrand. They are the ones who started this illness as part of their plan to build Penelope a young and beautiful new body. All she needs is Danny's half-human/half-ghost DNA to complete her ghostly plan. With Danny captured and Sam sick, it's up to Tucker to conquer his fear of hospitals and free Danny before Penelope gets what she's after.
Elenco: David Kaufman , Colleen O'Shaughnessey , Grey Griffin , Rickey D'Shon Collins , Rob Paulsen , Kath Soucie , S. Scott Bullock , Ron Perlman , Martin Mull , Dee Bradley Baker .