When a demon escapes from custody, Agent Murphy enlists the Charmed Ones to help, where they learn a government created virus is spreading amongst magical beings, that causes them to "hulk out". Meanwhile, Billie becomes infected with the virus and it's up to the sisters to find an antidote.
Elenco: Holly Marie Combs , Alyssa Milano , Rose McGowan , Brian Krause , Kaley Cuoco , Alyssa Milano , Dorian Gregory , Drew Fuller , Jason Lewis , Kaley Cuoco , Ashley Tisdale , Eric Dane , Finola Hughes , Greg Vaughan , Ivan Sergei , James Read , Jennifer Rhodes , Kerr Smith , Nick Lachey , Theodore William King .