When Piper contracts a life-threatening tropical virus that leaves her in intensive care, and to try to save her life, Prue and Phoebe cast an 'awakening' spell. However, since the spell was used for personal gain, the sisters can no longer sleep, and Piper's sickness spreads into an epidemic as a direct consequence. Meanwhile, Prue quits her job at Bucklands and Phoebe enrolls in university.
Elenco: Holly Marie Combs , Alyssa Milano , Rose McGowan , Brian Krause , Kaley Cuoco , Alyssa Milano , Dorian Gregory , Drew Fuller , Jason Lewis , Kaley Cuoco , Ashley Tisdale , Eric Dane , Finola Hughes , Greg Vaughan , Ivan Sergei , James Read , Jennifer Rhodes , Kerr Smith , Nick Lachey , Theodore William King .